L-α-glycerophosphorylcholine may be a supplemental source of choline.

L-α-Glycerophosphorylcholine

Found In

  • Beverages
  • Dietary supplements
  • Fruit and vegetable nectar

Also Known As

  • Alpha-GPC
  • Choline Alfoscerate
  • Glycerophosphocholine
  • GPC/Lecithin
  • L-Alpha Glycerylfosforylcholine

The Beverage Bottom Line

L-α-glycerophosphorylcholine is authorized for use in the U.S. and Canada. L-α-glycerophosphorylcholine has not yet been evaluated for use in beverages in Europe.

 

This ingredient may have authorizations in countries not included on this site.

International Assessments and Authorizations

U.S. Food And Drug Administration (FDA)

Affirmation by FDA this ingredient is generally recognized as safe as a direct human food ingredient. (GRAS FDA-Affirmed, GRAS FDA-Notified, GRAS Self-Determined)

In 2021, FDA issued no objections to a GRAS notice on sunflower lecithins.

In 2012, FDA issued no objection to a GRAS notice on L-alpha-glycerylphosphorylcholine.

In 2005 and 2006, dietary reference intakes for choline were reviewed by the National Academies of Sciences, Engineering and Medicine.

In 1983, FDA affirmed lecithin as GRAS.

In 1979, health aspects of lecithin as a food ingredient were evaluated.

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European Food Safety Authority (EFSA)

L-α-Glycerylphosphorylcholine is considered a novel food.

 

In 2017 and 2020, EFSA reaffirmed the safety of lecithin.

In 2016, EFSA established dietary reference values for choline.

In 2011, EFSA evaluated health claims related to choline.

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Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Safe for intended uses.

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Health Canada

Safe for intended uses. Permitted for use as a supplemental ingredient.

 

In 2005 and 2006, dietary reference intakes for choline were reviewed by the National Academies of Sciences, Engineering and Medicine.

 

 

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This page was last updated on 6/30/2025.